Drosophila_melanogasterFamily: RTC Number of Genes: 2
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Rtc1
Rtca

Introduction

Pfam

RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate [1]. The structure of RTC demonstrates that RTCs are comprised two domain. The larger domain contains an insert domain of approximately 100 amino acids [1].

InterPro

RNA cyclases are a family of RNA-modifying enzymes that are conserved in eukaryotes, bacteria and archaea. Type 1 RNA 3'-terminal phosphate cyclases (EC) [PUBMED:9184239, PUBMED:2199762] catalyse the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA:

Reference

  1. Palm GJ, Billy E, Filipowicz W, Wlodawer A; , Structure Fold Des 2000;8:13-23.: Crystal structure of RNA 3'-terminal phosphate cyclase, a ubiquitous enzyme with unusual topology. PUBMED:10673421 EPMC:10673421.