Homo_sapiensFamily: Ribosomal_L1 Number of Genes: 3
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
MRPL1
RSL1D1
RPL10A

Introduction

Pfam

This family includes prokaryotic L1 and eukaryotic L10.

InterPro

Ribosomal protein L1 is the largest protein from the large ribosomal subunit. The L1 protein contains two domains: 2-layer alpha/beta domain and a 3-layer alpha/beta domain (interrupts the first domain). The two domains cycle between open and closed conformations via a hinge motion. In Escherichia coli, L1 is known to bind to the 23S rRNA. The RNA-binding site of L1 is highly conserved, with both mRNA and rRNA binding the same binding site. Like several other large ribosomal subunit proteins, L1 displays RNA chaperone activity [PUBMED:17517772,PUBMED:15659579,PUBMED:16330048,PUBMED:12037305, PUBMED:10801481,PUBMED:12514741]. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [PUBMED:8635468, PUBMED:8607874], groups:

Reference

  1. No References