Ursus_americanusFamily: S1 Number of Genes: 8
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
SUPT6H
-
SRBD1
-
EIF2S1
-
PNPT1
-
PDCD11
-
DHX8
-
ZCCHC17
-
POLR2G
-

Introduction

Pfam

The S1 domain occurs in a wide range of RNA associated proteins. It is structurally similar to cold shock protein which binds nucleic acids. The S1 domain has an OB-fold structure.

InterPro

The S1 domain was originally identified in ribosomal protein S1 but is found in a large number of RNA-associated proteins. The structure of the S1 RNA-binding domain from the Escherichia coli polynucleotide phosphorylase has been determined using NMR methods and consists of a five-stranded antiparallel beta barrel. Conserved residues on one face of the barrel and adjacent loops form the putative RNA-binding site [PUBMED:9008164].

Reference

  1. Bycroft M, Hubbard TJ, Proctor M, Freund SM, Murzin AG; , Cell 1997;88:235-242.: The solution structure of the S1 RNA binding domain: a member of an ancient nucleic acid-binding fold. PUBMED:9008164 EPMC:9008164.