Microtus_ochrogasterFamily: SAP Number of Genes: 16
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Eri1
-
Safb2
Ccar1
Hnrnpul1
Rad18
Sltm
Safb
Hnrnpu
Xrcc6
-
-
Hnrnpul2
Mamstr
Mkl1
Myocd
Mkl2

Introduction

Pfam

The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.

InterPro

The SAP motif is a 35-residue motif, which has been named after SAF-A/B, Acinus and PIAS, three proteins known to contain it. The SAP motif is found in a variety of nuclear proteins involved in transcription, DNA repair, RNA processing or apoptotic chromatin degradation. As the sap motif of SAF-A has been shown to be essential for specific DNA binding activity, it has been proposed that it could be a DNA-binding motif [PUBMED:10694879].

Reference

  1. Aravind L, Koonin EV; , Trends Biochem Sci 2000;25:112-114.: SAP - a putative DNA-binding motif involved in chromosomal organization. PUBMED:10694879 EPMC:10694879 .

  2. Iida T, Kawaguchi R, Nakayama J; , Curr Biol. 2006;16:1459-1464.: Conserved ribonuclease, Eri1, negatively regulates heterochromatin assembly in fission yeast. PUBMED:16797182 EPMC:16797182.