EuRBPDB

Microtus_ochrogasterFamily: SAP Number of Genes: 16

Ensembl ID	Symbol	Entrez ID
ENSMOCG00000003319	Eri1	101992790
ENSMOCG00000006502	-	101992668
ENSMOCG00000006827	Safb2	101997244
ENSMOCG00000007793	Ccar1	101986395
ENSMOCG00000008200	Hnrnpul1	101986491
ENSMOCG00000009114	Rad18	101980282
ENSMOCG00000012419	Sltm	101990487
ENSMOCG00000014040	Safb	101997712
ENSMOCG00000015623	Hnrnpu	101986153
ENSMOCG00000015717	Xrcc6	102000618
ENSMOCG00000016935	-	-
ENSMOCG00000020000	Hnrnpul2	101981722
ENSMOCG00000020029	Mamstr	101985664
ENSMOCG00000021144	Mkl1	101990136
ENSMOCG00000021190	Myocd	102000877
ENSMOCG00000022536	Mkl2	101985229

Introduction

Pfam

The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.

InterPro

The SAP motif is a 35-residue motif, which has been named after SAF-A/B, Acinus and PIAS, three proteins known to contain it. The SAP motif is found in a variety of nuclear proteins involved in transcription, DNA repair, RNA processing or apoptotic chromatin degradation. As the sap motif of SAF-A has been shown to be essential for specific DNA binding activity, it has been proposed that it could be a DNA-binding motif [PUBMED:10694879].

Reference

Aravind L, Koonin EV; , Trends Biochem Sci 2000;25:112-114.: SAP - a putative DNA-binding motif involved in chromosomal organization. PUBMED:10694879 EPMC:10694879 .
Iida T, Kawaguchi R, Nakayama J; , Curr Biol. 2006;16:1459-1464.: Conserved ribonuclease, Eri1, negatively regulates heterochromatin assembly in fission yeast. PUBMED:16797182 EPMC:16797182.