Homo_sapiensFamily: SRP54_N Number of Genes: 2
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO



No Pfam abstract.


This entry represents the N-terminal helical bundle domain of the 54 kDa SRP54 component, a GTP-binding protein that interacts with the signal sequence when it emerges from the ribosome. SRP54 of the signal recognition particle has a three-domain structure: an N-terminal helical bundle domain, a GTPase domain, and the M-domain that binds the 7s RNA and also binds the signal sequence. The extreme C-terminal region is glycine-rich and lower in complexity and poorly conserved between species.


  1. Montoya G, Svensson C, Luirink J, Sinning I; , Nature 1997;385:365-368.: Crystal structure of the NG domain from the signal-recognition particle receptor FtsY. PUBMED:9002525 EPMC:9002525.