Homo_sapiensFamily: TRM Number of Genes: 2
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO



This enzyme EC: used S-AdoMet to methylate tRNA. The TRM1 gene of Saccharomyces cerevisiae is necessary for the N2,N2-dimethylguanosine modification of both mitochondrial and cytoplasmic tRNAs [1]. The enzyme is found in both eukaryotes and archaebacteria [2]


The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.


  1. Ellis SR, Hopper AK, Martin NC; , Proc Natl Acad Sci U S A 1987;84:5172-5176.: Amino-terminal extension generated from an upstream AUG codon is not required for mitochondrial import of yeast N2,N2-dimethylguanosine- specific tRNA methyltransferase. PUBMED:3299379 EPMC:3299379 .

  2. Constantinesco F, Benachenhou N, Motorin Y, Grosjean H; , Nucleic Acids Res 1998;26:3753-3761.: The tRNA(guanine-26,N2-N2) methyltransferase (Trm1) from the hyperthermophilic archaeon Pyrococcus furiosus: cloning, sequencing of the gene and its expression in Escherichia coli. PUBMED:9685492 EPMC:9685492.