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Members of this family include Translin Q15631 that interacts with DNA and forms a ring around the DNA. This family also includes Q99598 that was found to interact with translin with yeast two-hybrid screen .
Translins are DNA-binding proteins that specifically recognise consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. They seem to recognise single-stranded DNA ends generated by staggered breaks occuring at recombination hot spots [PUBMED:9013868]. Translin folds into an alpha-alpha superhelix, consisting of two curved layers of alpha/alpha topology [PUBMED:12079346, PUBMED:15039555].
Aoki K, Ishida R, Kasai M; , FEBS Lett 1997;401:109-112.: Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX. PUBMED:9013868 EPMC:9013868.