EuRBPDB

Haplochromis_burtoniFamily: UPF1_Zn_bind Number of Genes: 2
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
upf1 (1 of many)
upf1 (1 of many)

Introduction

Pfam

UPF1 is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation. This domain contains 3 zinc binding motifs and forms interactions with another protein (UPF2) that is also involved nonsense-mediated mRNA decay (NMD) [1].

InterPro

UPF1 (or regulator of nonsense transcripts 1 homologue) is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation. This domain contains 3 zinc binding motifs and forms interactions with another protein (UPF2) that is also involved nonsense-mediated mRNA decay (NMD) [PUBMED:16931876].

Reference

  1. Kadlec J, Guilligay D, Ravelli RB, Cusack S; , RNA. 2006;12:1817-1824.: Crystal structure of the UPF2-interacting domain of nonsense-mediated mRNA decay factor UPF1. PUBMED:16931876 EPMC:16931876.