This family aligns residues towards the N-terminus of several proteins with multiple functions. The members of this family all appear to possess 5'-3' exonuclease activity EC:3.1.11.-. Thus, the aligned region may be necessary for 5' to 3' exonuclease function. The family also contains several Xrn1 and Xrn2 proteins. The 5'-3' exoribonucleases Xrn1p and Xrn2p/Rat1p function in the degradation and processing of several classes of RNA in Saccharomyces cerevisiae. Xrn1p is the main enzyme catalysing cytoplasmic mRNA degradation in multiple decay pathways, whereas Xrn2p/Rat1p functions in the processing of rRNAs and small nucleolar RNAs (snoRNAs) in the nucleus .
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
Till DD, Linz B, Seago JE, Elgar SJ, Marujo PE, Elias ML, Arraiano CM, McClellan JA, McCarthy JE, Newbury SF; , Mech Dev 1998;79:51-55.: Identification and developmental expression of a 5'-3' exoribonuclease from Drosophila melanogaster. PUBMED:10349620 EPMC:10349620 .
Kastenmayer JP, Green PJ; , Proc Natl Acad Sci U S A 2000;97:13985-13990.: Novel features of the XRN-family in Arabidopsis: evidence that AtXRN4, one of several orthologs of nuclear Xrn2p/Rat1p, functions in the cytoplasm. PUBMED:11106401 EPMC:11106401.