This family aligns residues towards the N-terminus of several proteins with multiple functions. The members of this family all appear to possess 5'-3' exonuclease activity EC:3.1.11.-. Thus, the aligned region may be necessary for 5' to 3' exonuclease function. The family also contains several Xrn1 and Xrn2 proteins. The 5'-3' exoribonucleases Xrn1p and Xrn2p/Rat1p function in the degradation and processing of several classes of RNA in Saccharomyces cerevisiae. Xrn1p is the main enzyme catalysing cytoplasmic mRNA degradation in multiple decay pathways, whereas Xrn2p/Rat1p functions in the processing of rRNAs and small nucleolar RNAs (snoRNAs) in the nucleus [3].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
Szankasi P, Smith GR; , Curr Genet 1996;30:284-293.: Requirement of S. pombe exonuclease II, a homologue of S. cerevisiae Sep1, for normal mitotic growth and viability. PUBMED:8781170 EPMC:8781170 .
Till DD, Linz B, Seago JE, Elgar SJ, Marujo PE, Elias ML, Arraiano CM, McClellan JA, McCarthy JE, Newbury SF; , Mech Dev 1998;79:51-55.: Identification and developmental expression of a 5'-3' exoribonuclease from Drosophila melanogaster. PUBMED:10349620 EPMC:10349620 .
Kastenmayer JP, Green PJ; , Proc Natl Acad Sci U S A 2000;97:13985-13990.: Novel features of the XRN-family in Arabidopsis: evidence that AtXRN4, one of several orthologs of nuclear Xrn2p/Rat1p, functions in the cytoplasm. PUBMED:11106401 EPMC:11106401.
