Homo_sapiensFamily: eIF-3c_N Number of Genes: 2
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO



The largest of the mammalian translation initiation factors, eIF3, consists of at least eight subunits ranging in mass from 35 to 170 kDa. eIF3 binds to the 40 S ribosome in an early step of translation initiation and promotes the binding of methionyl-tRNAi and mRNA [1].


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  1. Asano K, Kinzy TG, Merrick WC, Hershey JW; , J Biol Chem 1997;272:1101-1109.: Conservation and diversity of eukaryotic translation initiation factor eIF3. PUBMED:8995409 EPMC:8995409 .

  2. Valasek L, Nielsen KH, Hinnebusch AG; , EMBO J 2002;21:5886-5898.: Direct eIF2-eIF3 contact in the multifactor complex is important for translation initiation in vivo. PUBMED:12411506 EPMC:12411506.