EuRBPDB

Gambusia_affinisFamily: rRNA_proc-arch Number of Genes: 2

Ensembl ID	Symbol	Entrez ID	RBD	RBPome	PRI	Expresion	Pathway	Phenotype	Paralog	Ortholog	GO
ENSGAFG00000002382	skiv2l	-
ENSGAFG00000012425	mtrex	-

Introduction

Pfam

Mtr4 is the essential RNA helicase, and is an exosome-activating cofactor. This arch domain is carried in Mtr4 and Ski2 (the cytosolic homologue of Mtr4). The arch domain is required for proper 5.8S rRNA processing, and appears to function independently of canonical helicase activity [1].

InterPro

The essential RNA helicase Mtr4 is an exosome-activating cofactor. This arch domain can be found in Mtr4 and Ski2 (the cytosolic homologue of Mtr4). The arch domain is required for proper 5.8S rRNA processing, and appears to function independently of canonical helicase activity [PUBMED:20512111].

Reference

Jackson RN, Klauer AA, Hintze BJ, Robinson H, van Hoof A, Johnson SJ;, EMBO J. 2010;29:2205-2216.: The crystal structure of Mtr4 reveals a novel arch domain required for rRNA processing. PUBMED:20512111 EPMC:20512111.