Rhinopithecus_roxellanaFamily: zf-C2H2 Number of Genes: 89
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
ZNF524
ZNF683
ZFAT
ZNF808
-
ZBTB38
PRDM4
ZBTB34
ZSCAN5B
ZBTB26
ZBTB49
ZNF205
-
WT1
-
ZNF319
ZNF836
BCL6
MAZ
ZNF768
ZIC3
BNC2
ZBTB24
ZBTB6
ZBTB14
-
-
ZNF829
ZBTB20
ZBTB47
ZNF784
GZF1
ZNF700
ZNF233
-
ZBTB37
ZNF468
-
ZBTB41
ZFHX4
ZNF423
ZNF791
GFI1
HIC1
-
ZNF225
SNAI2
ZNF28
SNAI3
ZNF235
ZNF816
SALL3
-
KMT2B
PRDM10
ZBTB40
ZNF226
ZNF384
ZNF112
HIC2
PRDM5
SALL2
-
ZBTB44
SALL1
ZNF582
ZNF888
SALL4
ZEB2
ZBTB16
PATZ1
ZNF687
-
ZNF337
ZNF236
ZNF574
-
RREB1
ZFHX3
ZNF628
-
ZNF550
ZNF800
ZSCAN5A
ZSCAN5C
ZNF267
ZEB1
ZFP64
ZFP1
GTF3A
-
PRDM12
-
SNAI1
BCL6B
ZNF850
ZNF652
ZNF701
-
ZNF317
-
-

Introduction

Pfam

The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [2].

InterPro

No InterPro abstract

Reference

  1. Boehm S, Frishman D, Mewes HW; , Nucleic Acids Res 1997;25:2464-2469.: Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. PUBMED:9171100 EPMC:9171100 .

  2. Marco E, Garcia-Nieto R, Gago F; , J Mol Biol 2003;328:9-32.: Assessment by molecular dynamics simulations of the structural determinants of DNA-binding specificity for transcription factor Sp1. PUBMED:12683994 EPMC:12683994.