EuRBPDB

Gambusia_affinisFamily: CPSF_A Number of Genes: 3
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
ddb1
-
sf3b3
-
cpsf1
-

Introduction

Pfam

This family includes a region that lies towards the C-terminus of the cleavage and polyadenylation specificity factor (CPSF) A (160 kDa) subunit. CPSF is involved in mRNA polyadenylation and binds the AAUAAA conserved sequence in pre-mRNA. CPSF has also been found to be necessary for splicing of single-intron pre-mRNAs [1]. The function of the aligned region is unknown but may be involved in RNA/DNA binding.

InterPro

This family includes a region that lies towards the C terminus of the cleavage and polyadenylation specificity factor (CPSF) A (160 kDa) subunit. CPSF is involved in mRNA polyadenylation and binds the AAUAAA conserved sequence in pre-mRNA. CPSF has also been found to be necessary for splicing of single-intron pre-mRNAs [PUBMED:11421366]. The function of the aligned region is unknown but may be involved in RNA/DNA binding.

Gene Ontology

  • Cellular component: nucleus (GO:0005634)
  • Molecular function: nucleic acid binding (GO:0003676)

Reference

  1. Li Y, Chen ZY, Wang W, Baker CC, Krug RM; , RNA 2001;7:920-931.: The 3'-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAs in vivo. PUBMED:11421366 EPMC:11421366.