EuRBPDB

Mus_caroliFamily: EST1 Number of Genes: 3

Ensembl ID	Symbol	Entrez ID
MGP_CAROLIEiJ_G0014704	Smg7	110305373
MGP_CAROLIEiJ_G0016729	Smg6	110304701
MGP_CAROLIEiJ_G0025163	Smg5	110290762

Introduction

Pfam

Est1 is a protein which recruits or activates telomerase at the site of polymerisation [1]. Structurally it resembles a TPR-like repeat.

InterPro

Est1 is directly involved in telomere replication. It associates with telomerase and, during its interaction with CDC13, telomerase activity is promoted [PUBMED:12169735, PUBMED:12454059].

Reference

Taggart AK, Teng SC, Zakian VA; , Science. 2002;297:1023-1026.: Est1p as a cell cycle-regulated activator of telomere-bound telomerase. PUBMED:12169735 EPMC:12169735 .
Evans SK, Lundblad V; , Genetics. 2002;162:1101-1115.: The Est1 subunit of Saccharomyces cerevisiae telomerase makes multiple contributions to telomere length maintenance. PUBMED:12454059 EPMC:12454059 .
Beernink HT, Miller K, Deshpande A, Bucher P, Cooper JP; , Curr Biol. 2003;13:575-580.: Telomere maintenance in fission yeast requires an Est1 ortholog. PUBMED:12676088 EPMC:12676088.