Homo_sapiensFamily: EST1_DNA_bind Number of Genes: 3
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO



Est1 is a protein which recruits or activates telomerase at the site of polymerisation [1]. This is the DNA/RNA binding domain of EST1 [3].


This entry represents a DNA/RNA binding domain found in the telomere elongation protein EST1 and related sequences, such as the nonsense-mediated mRNA decay pathway proteins SMG5 and SMG7 [PUBMED:12676088, PUBMED:14636577, PUBMED:15546618].


  1. Taggart AK, Teng SC, Zakian VA; , Science. 2002;297:1023-1026.: Est1p as a cell cycle-regulated activator of telomere-bound telomerase. PUBMED:12169735 EPMC:12169735 .

  2. Evans SK, Lundblad V; , Genetics. 2002;162:1101-1115.: The Est1 subunit of Saccharomyces cerevisiae telomerase makes multiple contributions to telomere length maintenance. PUBMED:12454059 EPMC:12454059 .

  3. Beernink HT, Miller K, Deshpande A, Bucher P, Cooper JP; , Curr Biol. 2003;13:575-580.: Telomere maintenance in fission yeast requires an Est1 ortholog. PUBMED:12676088 EPMC:12676088 .

  4. Zhou J, Hidaka K, Futcher B;, Mol Cell Biol. 2000;20:1947-1955.: The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA. PUBMED:10688642 EPMC:10688642.