Esox_luciusFamily: FDF Number of Genes: 6
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
lsm14b
edc3
lsm14ab
EDC3 (1 of many)
LSM14B (1 of many)
lsm14aa

Introduction

Pfam

The FDF domain, so called because of the conserved FDF at its N termini, is an entirely alpha-helical domain with multiple exposed hydrophilic loops [1]. It is found at the C terminus of Scd6p-like SM domains [1]. It is also found with other divergent Sm domains and in proteins such as Dcp3p and FLJ21128, where it is found N terminal to the YjeF-N domain, a novel Rossmann fold domain [1].

InterPro

The FDF domain, so called because of the conserved FDF at its N termini, is an entirely alpha-helical domain with multiple exposed hydrophilic loops [PUBMED:15257761]. It is found at the C terminus of Scd6p-like SM domains [PUBMED:15257761, PUBMED:15225602]. It is also found with other divergent Sm domains and in proteins such as Dcp3p and FLJ21128, where it is found N-terminal to the YjeF-N domain, a novel Rossmann fold domain [PUBMED:15257761].

Reference

  1. Anantharaman V, Aravind L;, BMC Genomics. 2004;5:45.: Novel conserved domains in proteins with predicted roles in eukaryotic cell-cycle regulation, decapping and RNA stability. PUBMED:15257761 EPMC:15257761 .

  2. Albrecht M, Lengauer T; , FEBS Lett 2004;569:18-26.: Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. PUBMED:15225602 EPMC:15225602 .

  3. Tritschler F, Braun JE, Eulalio A, Truffault V, Izaurralde E, Weichenrieder O;, Mol Cell. 2009;33:661-668.: Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. PUBMED:19285948 EPMC:19285948.