EuRBPDB

Anabas_testudineusFamily: LSM Number of Genes: 18

Ensembl ID	Symbol	Entrez ID
ENSATEG00000000868	snrpd2	-
ENSATEG00000001072	naa38	113157651
ENSATEG00000005153	lsm3	113153174
ENSATEG00000005274	snrpe	113151674
ENSATEG00000005597	-	113151693
ENSATEG00000006310	oscp1a	-
ENSATEG00000008557	lsm7	113151551
ENSATEG00000009836	snrpb	113155248
ENSATEG00000011376	si:ch73-14h10.2	113152328
ENSATEG00000012610	lsm6	113161412
ENSATEG00000014399	snrpd1	113153358
ENSATEG00000016559	lsm4	113150901
ENSATEG00000020470	lsm5	-
ENSATEG00000020556	snrpd3l	113147874
ENSATEG00000022266	lsm1	113150808
ENSATEG00000022625	snrpf	-
ENSATEG00000023229	snrpg	113167744
ENSATEG00000023432	lsm8	-

Introduction

Pfam

The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.

InterPro

This domain is found in Lsm (like-Sm) proteins, which have a core structure consisting of an open beta-barrel with an SH3-like topology.

Reference

Hermann H, Fabrizio P, Raker VA, Foulaki K, Hornig H, Brahms H, Luhrmann R , EMBO J 1995;14:2076-2088.: snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions. PUBMED:7744013 EPMC:7744013 .
Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Luhrmann R, Li J, Nagai K; , Cell 1999;96:375-387.: Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs. PUBMED:10025403 EPMC:10025403 .
Mayes AE, Verdone L, Legrain P, Beggs JD; , EMBO J 1999;18:4321-4331.: Characterization of Sm-like proteins in yeast and their association with U6 snRNA. PUBMED:10428970 EPMC:10428970 .
Hajnsdorf E, Regnier P; , Proc Natl Acad Sci U S A 2000;97:1501-1505.: Host factor Hfq of Escherichia coli stimulates elongation of poly(A) tails by poly(A) polymerase I. PUBMED:10677490 EPMC:10677490 .
Vytvytska O, Moll I, Kaberdin VR, von Gabain A, Blasi U; , Genes Dev 2000;14:1109-1118.: Hfq (HF1) stimulates ompA mRNA decay by interfering with ribosome binding. PUBMED:10809669 EPMC:10809669 .
Kufel J, Allmang C, Petfalski E, Beggs J, Tollervey D; , J Biol Chem 2003;278:2147-2156.: Lsm Proteins are required for normal processing and stability of ribosomal RNAs. PUBMED:12438310 EPMC:12438310.