EuRBPDB

Mus_musculus_c3hhejFamily: LSM Number of Genes: 21

Ensembl ID	Symbol	Entrez ID
MGP_C3HHeJ_G0016257	Snrpe	-
MGP_C3HHeJ_G0017117	Snrpd3	-
MGP_C3HHeJ_G0017287	-	-
MGP_C3HHeJ_G0017419	Snrpf	-
MGP_C3HHeJ_G0018285	Naa38	-
MGP_C3HHeJ_G0020312	Gm5449	-
MGP_C3HHeJ_G0023331	Lsm2	-
MGP_C3HHeJ_G0023877	Snrpd1	-
MGP_C3HHeJ_G0025044	-	-
MGP_C3HHeJ_G0026214	Snrpb	-
MGP_C3HHeJ_G0028466	Lsm10	-
MGP_C3HHeJ_G0028620	Gm8186	-
MGP_C3HHeJ_G0030173	Lsm8	-
MGP_C3HHeJ_G0030473	Lsm5	-
MGP_C3HHeJ_G0030679	Lsm3	-
MGP_C3HHeJ_G0030758	Snrpg	-
MGP_C3HHeJ_G0031465	Snrpd2	-
MGP_C3HHeJ_G0032028	Snrpn	-
MGP_C3HHeJ_G0033178	Lsm1	-
MGP_C3HHeJ_G0033407	Lsm4	-
MGP_C3HHeJ_G0033493	Lsm6	-

Introduction

Pfam

The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.

InterPro

This domain is found in Lsm (like-Sm) proteins, which have a core structure consisting of an open beta-barrel with an SH3-like topology.

Reference

Hermann H, Fabrizio P, Raker VA, Foulaki K, Hornig H, Brahms H, Luhrmann R , EMBO J 1995;14:2076-2088.: snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions. PUBMED:7744013 EPMC:7744013 .
Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Luhrmann R, Li J, Nagai K; , Cell 1999;96:375-387.: Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs. PUBMED:10025403 EPMC:10025403 .
Mayes AE, Verdone L, Legrain P, Beggs JD; , EMBO J 1999;18:4321-4331.: Characterization of Sm-like proteins in yeast and their association with U6 snRNA. PUBMED:10428970 EPMC:10428970 .
Hajnsdorf E, Regnier P; , Proc Natl Acad Sci U S A 2000;97:1501-1505.: Host factor Hfq of Escherichia coli stimulates elongation of poly(A) tails by poly(A) polymerase I. PUBMED:10677490 EPMC:10677490 .
Vytvytska O, Moll I, Kaberdin VR, von Gabain A, Blasi U; , Genes Dev 2000;14:1109-1118.: Hfq (HF1) stimulates ompA mRNA decay by interfering with ribosome binding. PUBMED:10809669 EPMC:10809669 .
Kufel J, Allmang C, Petfalski E, Beggs J, Tollervey D; , J Biol Chem 2003;278:2147-2156.: Lsm Proteins are required for normal processing and stability of ribosomal RNAs. PUBMED:12438310 EPMC:12438310.