Mus_musculus_c3hhejFamily: LSM Number of Genes: 21
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Snrpe
-
Snrpd3
-
-
-
Snrpf
-
Naa38
-
Gm5449
-
Lsm2
-
Snrpd1
-
-
-
Snrpb
-
Lsm10
-
Gm8186
-
Lsm8
-
Lsm5
-
Lsm3
-
Snrpg
-
Snrpd2
-
Snrpn
-
Lsm1
-
Lsm4
-
Lsm6
-

Introduction

Pfam

The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.

InterPro

This domain is found in Lsm (like-Sm) proteins, which have a core structure consisting of an open beta-barrel with an SH3-like topology.

Reference

  1. Hermann H, Fabrizio P, Raker VA, Foulaki K, Hornig H, Brahms H, Luhrmann R , EMBO J 1995;14:2076-2088.: snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions. PUBMED:7744013 EPMC:7744013 .

  2. Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Luhrmann R, Li J, Nagai K; , Cell 1999;96:375-387.: Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs. PUBMED:10025403 EPMC:10025403 .

  3. Mayes AE, Verdone L, Legrain P, Beggs JD; , EMBO J 1999;18:4321-4331.: Characterization of Sm-like proteins in yeast and their association with U6 snRNA. PUBMED:10428970 EPMC:10428970 .

  4. Hajnsdorf E, Regnier P; , Proc Natl Acad Sci U S A 2000;97:1501-1505.: Host factor Hfq of Escherichia coli stimulates elongation of poly(A) tails by poly(A) polymerase I. PUBMED:10677490 EPMC:10677490 .

  5. Vytvytska O, Moll I, Kaberdin VR, von Gabain A, Blasi U; , Genes Dev 2000;14:1109-1118.: Hfq (HF1) stimulates ompA mRNA decay by interfering with ribosome binding. PUBMED:10809669 EPMC:10809669 .

  6. Kufel J, Allmang C, Petfalski E, Beggs J, Tollervey D; , J Biol Chem 2003;278:2147-2156.: Lsm Proteins are required for normal processing and stability of ribosomal RNAs. PUBMED:12438310 EPMC:12438310.