Mandrillus_leucophaeusFamily: MMR_HSR1 Number of Genes: 107
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
DRG1
RRAGB
-
NKIRAS2
IRGC
ARL11
RAB9A
SEPT12
EHD3
RAB25
RRAGA
NOA1
IFI44L
-
-
ARL4D
ARL4C
-
GNL3
RAB9B
RABL3
-
ARL14
KRAS
-
GTPBP3
RAB5A
RAB39B
-
RASL11B
-
-
-
GNL3L
GIMAP6
ARL5B
ARL10
RAB3C
GNL1
GIMAP4
SEPT6
-
SEPT9
MTIF2
-
-
GPN1
EIF5B
RAB14
RAB33A
EHD1
SRL
-
SEPT14
RAB11A
-
GUF1
GIMAP2
RAB33B
GIMAP7
-
RAB18
MFN1
RAB36
ARFRP1
RAB44
RAB34
-
RAB5B
RASEF
SRPRB
RAB22A
GIMD1
-
RASL11A
-
GTPBP8
ARL1
GIMAP8
-
GTPBP10
DRG2
ARL3
SAR1A
RAB41
ARF4
SAR1B
ARL8B
RAB6A
-
-
NRAS
SEPT1
RAB30
ARL5A
GTPBP4
-
-
-
OLA1
ERAL1
ARF1
RAB7A
MTG2
-
RAB1B
LSG1
SEPT11
HRAS
-
RAB23
RAB1A
RAB2B
SEPT2
RERG
CRACR2A
SEPT8
ARL6
ARL2
GNL2

Introduction

Pfam

The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.

InterPro

Several proteins have recently been shown to contain the 5 structural motifs characteristic of GTP-binding proteins [PUBMED:1449490]. These include murine DRG protein; GTP1 protein from Schizosaccharomyces pombe; OBG protein from Bacillus subtilis [PUBMED:12429099]; ferrous iron transport protein B [PUBMED:20123128] and several others.

Reference

  1. Vernet C, Ribouchon MT, Chimini GPontarotti P; , Mamm Genome 1994;5:100-105.: Structure and evolution of a member of a new subfamily of GTP-binding proteins mapping to the human MHC class I region. PUBMED:8180467 EPMC:8180467 .

  2. Bassler J, Kallas M, Hurt E;, J Biol Chem. 2006;281:24737-24744.: The NUG1 GTPase reveals and N-terminal RNA-binding domain that is essential for association with 60 S pre-ribosomal particles. PUBMED:16803892 EPMC:16803892 .

  3. Jain N, Dhimole N, Khan AR, De D, Tomar SK, Sajish M, Dutta D, Parrack P, Prakash B;, Biochem Biophys Res Commun. 2009;379:201-205.: E. coli HflX interacts with 50S ribosomal subunits in presence of nucleotides. PUBMED:19109926 EPMC:19109926 .

  4. Dutta D, Bandyopadhyay K, Datta AB, Sardesai AA, Parrack P;, J Bacteriol. 2009;191:2307-2314.: Properties of HflX, an enigmatic protein from Escherichia coli. PUBMED:19181811 EPMC:19181811 .

  5. Shields MJ, Fischer JJ, Wieden HJ;, Biochemistry. 2009;48:10793-10802.: Toward understanding the function of the universally conserved GTPase HflX from Escherichia coli: a kinetic approach. PUBMED:19824612 EPMC:19824612.