EuRBPDB

Haplochromis_burtoniFamily: Exo_endo_phos Number of Genes: 27

Ensembl ID	Symbol	Entrez ID
ENSHBUG00000000026	-	102311120
ENSHBUG00000001285	-	102298468
ENSHBUG00000001687	noctb	-
ENSHBUG00000002468	angel2	102311601
ENSHBUG00000002714	tdp2b	102293334
ENSHBUG00000002819	cnot6b	102301704
ENSHBUG00000004755	cnot6l	102310426
ENSHBUG00000005421	-	102309531
ENSHBUG00000005894	apex1	102293445
ENSHBUG00000007774	synj1	102304674
ENSHBUG00000008702	inpp5ka	102307500
ENSHBUG00000008724	INPP5A	102293318
ENSHBUG00000009350	inpp5b	102312926
ENSHBUG00000009938	apex2	102295689
ENSHBUG00000010676	-	-
ENSHBUG00000012395	inpp5l	-
ENSHBUG00000013397	inpp5d	102298072
ENSHBUG00000014481	inppl1b	102293417
ENSHBUG00000014999	inpp5kb	102306066
ENSHBUG00000015510	inppl1a	102291662
ENSHBUG00000015936	-	-
ENSHBUG00000016975	ocrl	102298254
ENSHBUG00000017212	smpd5	102309044
ENSHBUG00000018316	angel1	102295717
ENSHBUG00000021461	inpp5ja	-
ENSHBUG00000021709	dnase1l1l	102307362
ENSHBUG00000023370	pde12	102308216

Introduction

Pfam

This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g P27695 DNase I proteins EC:3.1.21.1 e.g. P24855 Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 O43426 Sphingomyelinase EC:3.1.4.12 P11889 and Nocturnin O35710.

InterPro

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PUBMED:10838565]. Proteins this domain is found in include: AP endonuclease proteins (EC), DNase I proteins (EC), Synaptojanin an inositol-1,4,5-trisphosphate phosphatase (EC) and Sphingomyelinase (EC).

Reference

Dlakic M; , Trends Biochem Sci 2000;25:272-273.: Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases. PUBMED:10838565 EPMC:10838565 .
Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA; , Nature 1995;374:381-386.: Structure and function of the multifunctional DNA-repair enzyme exonuclease III. PUBMED:7885481 EPMC:7885481 .
Lahm A, Suck D; , J Mol Biol 1991;222:645-667.: DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex. PUBMED:1748997 EPMC:1748997.