Maylandia_zebraFamily: LSM14 Number of Genes: 6
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
EDC3 (1 of many)
LSM14B (1 of many)



The Scd6-like Sm domain is found in Scd6p from S. cerevisiae, Rap55 from the newt Pleurodeles walt, and its orthologs from fungi, animals, plants and apicomplexans [1]. The domain is also found in Dcp3p and the human EDC3/FLJ21128 protein where it is fused to the the Rossmanoid YjeF-N domain [1,2]. In addition both EDC3 and Scd6p are found fused to the FDF domain [1,2].


The Lsm14 N-terminal domain is a type of LSM domain found in Lsm14 proteins (also known as Rap55) [PUBMED:17074753, PUBMED:18723115] and in the Saccharomyces cerevisiae homologue Scd6 [PUBMED:15225602]. The domain is also found in the human EDC3 protein (enhancer of mRNA-decapping protein 3) where it is fused to the the Rossmanoid YjeF-N domain [PUBMED:15257761]. In addition, both EDC3 and Scd6 are found fused to the FDF domain [PUBMED:15225602, PUBMED:15257761].


  1. Anantharaman V, Aravind L;, BMC Genomics. 2004;5:45.: Novel conserved domains in proteins with predicted roles in eukaryotic cell-cycle regulation, decapping and RNA stability. PUBMED:15257761 EPMC:15257761 .

  2. Albrecht M, Lengauer T; , FEBS Lett 2004;569:18-26.: Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. PUBMED:15225602 EPMC:15225602 .

  3. Tanaka KJ, Ogawa K, Takagi M, Imamoto N, Matsumoto K, Tsujimoto M;, J Biol Chem. 2006;281:40096-40106.: RAP55, a cytoplasmic mRNP component, represses translation in Xenopus oocytes. PUBMED:17074753 EPMC:17074753 .

  4. Marnef A, Sommerville J, Ladomery MR;, Int J Biochem Cell Biol. 2009;41:977-981.: RAP55: insights into an evolutionarily conserved protein family. PUBMED:18723115 EPMC:18723115 .

  5. Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S, Schmidt S, Coles M, Izaurralde E, Weichenrieder O; , Mol Cell Biol. 2007;27:8600-8611.: A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting. PUBMED:17923697 EPMC:17923697.