Microcebus_murinusFamily: zf-C2H2 Number of Genes: 83
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
SALL4
-
PRDM5
ZNF646
ZBTB37
ZNF829
ZFHX3
ZBTB12
RREB1
WT1
ZNF319
ZNF235
ZNF112
ZNF423
PATZ1
ZEB1
ZNF354A
ZNF652
ZBTB40
ZNF550
-
PRDM4
ZFHX4
ZBTB44
ZNF205
ZBTB16
ZNF551
HIC1
ZNF582
BNC2
PRDM15
PRDM10
ZNF277
ZNF574
-
ZBTB24
GTF3A
ZFP1
PRDM12
ZNF532
-
ZNF687
-
ZNF226
ZNF233
SALL3
-
ZEB2
-
MAZ
ZNF800
ZNF2
ZNF564
ZNF317
ZFPM1
OVOL2
-
ZFP64
ZBTB14
ZNF784
SALL1
ZBTB34
ZNF768
ZNF81
ZBTB26
BCL6B
SNAI1
ZBTB49
ZIC3
-
-
ZNF345
-
ZBTB41
-
HIC2
ZNF408
-
ZBTB32
GZF1
SALL2
GFI1
ZBTB6
SLC27A5
BCL6
ZBTB20
MYNN
ZBTB47

Introduction

Pfam

The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [2].

InterPro

No InterPro abstract

Reference

  1. Boehm S, Frishman D, Mewes HW; , Nucleic Acids Res 1997;25:2464-2469.: Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. PUBMED:9171100 EPMC:9171100 .

  2. Marco E, Garcia-Nieto R, Gago F; , J Mol Biol 2003;328:9-32.: Assessment by molecular dynamics simulations of the structural determinants of DNA-binding specificity for transcription factor Sp1. PUBMED:12683994 EPMC:12683994.