Oreochromis_niloticusFamily: zf-C2H2 Number of Genes: 201
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
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zbtb24
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zbtb18
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znf652
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GZF1
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znf710b
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sall1a
prdm12b
prdm5
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patz1
zgc:171929
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bcl6b
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znf384l
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zbtb20
hinfp
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wt1b
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zbtb47b
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zfhx3
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scrt1b
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znf236
sall3a
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znf341
si:dkey-89b17.4
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zbtb16a
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snai2
ZBTB14
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gfi1aa
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bcl6ab
zbtb41
zfpm1
zbtb34
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wt1a
znf319b
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zbtb16b
PRDM15
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zeb2b
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gfi1b
ZNF384
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prdm1b
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sall3b
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hic2
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zfhx4
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zbtb44
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znf131
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sall4
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scrt2
znf800a
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bnc2
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znf648
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gfi1ab
bcl6aa
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snai1a
zbtb49
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ZNF319
si:ch211-236k19.4
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hic1
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insm1b
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insm1a

Introduction

Pfam

The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [2].

InterPro

No InterPro abstract

Reference

  1. Boehm S, Frishman D, Mewes HW; , Nucleic Acids Res 1997;25:2464-2469.: Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. PUBMED:9171100 EPMC:9171100 .

  2. Marco E, Garcia-Nieto R, Gago F; , J Mol Biol 2003;328:9-32.: Assessment by molecular dynamics simulations of the structural determinants of DNA-binding specificity for transcription factor Sp1. PUBMED:12683994 EPMC:12683994.