EuRBPDB

Cavia_porcellusFamily: Exo_endo_phos Number of Genes: 23

Ensembl ID	Symbol	Entrez ID
ENSCPOG00000001186	EEPD1	100714673
ENSCPOG00000001620	PDE12	100724167
ENSCPOG00000003102	SMPD2	100714834
ENSCPOG00000003827	NOCT	100713041
ENSCPOG00000003875	ANGEL2	100714231
ENSCPOG00000005648	DNASE1L1	100734307
ENSCPOG00000006390	TDP2	100724093
ENSCPOG00000007265	APEX2	100722391
ENSCPOG00000008650	INPP5B	100722491
ENSCPOG00000009144	SYNJ2	100716353
ENSCPOG00000009596	INPP5E	100715053
ENSCPOG00000010337	CNOT6L	100719915
ENSCPOG00000011364	INPP5D	100722743
ENSCPOG00000011475	ANGEL1	100716556
ENSCPOG00000012182	SYNJ1	100720332
ENSCPOG00000012375	INPP5J	100731968
ENSCPOG00000013608	OCRL	100733180
ENSCPOG00000014786	INPPL1	100725170
ENSCPOG00000015072	INPP5A	100729042
ENSCPOG00000030909	APEX1	100719062
ENSCPOG00000035657	CNOT6	100715268
ENSCPOG00000038516	DNASE1L3	100721857
ENSCPOG00000040802	DNASE1L2	100733461

Introduction

Pfam

This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g P27695 DNase I proteins EC:3.1.21.1 e.g. P24855 Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 O43426 Sphingomyelinase EC:3.1.4.12 P11889 and Nocturnin O35710.

InterPro

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PUBMED:10838565]. Proteins this domain is found in include: AP endonuclease proteins (EC), DNase I proteins (EC), Synaptojanin an inositol-1,4,5-trisphosphate phosphatase (EC) and Sphingomyelinase (EC).

Reference

Dlakic M; , Trends Biochem Sci 2000;25:272-273.: Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases. PUBMED:10838565 EPMC:10838565 .
Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA; , Nature 1995;374:381-386.: Structure and function of the multifunctional DNA-repair enzyme exonuclease III. PUBMED:7885481 EPMC:7885481 .
Lahm A, Suck D; , J Mol Biol 1991;222:645-667.: DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex. PUBMED:1748997 EPMC:1748997.