EuRBPDB

Mus_musculusFamily: MIF4G Number of Genes: 17

Ensembl ID	Symbol	Entrez ID
ENSMUSG00000001569	Nom1	433864
ENSMUSG00000005610	Eif4g2	13690
ENSMUSG00000020743	Mif4gd	69674
ENSMUSG00000025451	Paip1	218693
ENSMUSG00000027014	Cwc22	80744
ENSMUSG00000028330	Ncbp1	433702
ENSMUSG00000028760	Eif4g3	230861
ENSMUSG00000043241	Upf2	326622
ENSMUSG00000045983	Eif4g1	208643
ENSMUSG00000052928	Ctif	269037
ENSMUSG00000079247	Gm13691	-
ENSMUSG00000094125	Gm13698	-
ENSMUSG00000094336	Gm13693	-
ENSMUSG00000095824	Gm13697	-
ENSMUSG00000096337	Gm13694	-
ENSMUSG00000096484	Gm13696	-
ENSMUSG00000096729	Gm13695	-

Introduction

Pfam

MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA [1].

InterPro

MIF4G stands for middle domain of eukaryotic initiation factor 4G (eIF4G). eIF4G is a component of the translation initiation factor eIF4F complex and the cytoplasmic cap-binding protein complex (CBC). In the cytoplasm, cap binding complexes, distinct in their composition from nuclear cap-binding complexes, have important roles in the initiation of mRNA translation.

Reference

Ponting CP; , Trends Biochem Sci 2000;25:423-426.: Novel eIF4G domain homologues linking mRNA translation with nonsense-mediated mRNA decay. PUBMED:10973054 EPMC:10973054.