Pongo_abeliiFamily: MMR_HSR1 Number of Genes: 105
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
ARF1
ARL8A
RAB25
-
NRAS
IFI44L
GNL2
GTPBP4
ARL5B
-
RAB18
SAR1A
ARL3
-
-
HRAS
-
EHD1
RAB6A
RAB30
RERG
KRAS
-
ARF3
ARL1
RAB35
RASL11A
RAB2B
-
EHD4
RAB11A
SRL
-
-
-
DRG2
-
ERAL1
SEPT4
ARL4D
RAB5C
NKIRAS2
-
-
-
-
-
-
EEF2
RAB11B
GTPBP3
-
IRGC
EHD2
-
RAB22A
MTG2
ARFRP1
-
-
RAB36
SEPT3
-
-
EIF5B
-
RAB1A
MTIF2
EHD3
GPN1
-
DNAJC27
ARL5A
OLA1
ARL4C
-
SEPT2
RAB7A
EEFSEC
RABL3
GTPBP8
ARL8B
ARF4
GNL3
RAB5A
SRPRB
RAB6B
ARL14
MFN1
-
LSG1
-
GUF1
NOA1
RASL11B
SEPT11
RAB33B
SEPT8
-
SAR1B
GNL1
-
-
RAB23
SEPT14
-
SEPT7
GTPBP10
GIMAP8
-
GIMAP4
GIMAP2
-
-
-
-
-
RAB2A
RRAGA
RASEF
-
-
GNL3L
-
RRAGB
RAB9B
SEPT6
-
RAB33A
RAB39B
ARL4A
GIMAP1
-
-

Introduction

Pfam

The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.

InterPro

Several proteins have recently been shown to contain the 5 structural motifs characteristic of GTP-binding proteins [PUBMED:1449490]. These include murine DRG protein; GTP1 protein from Schizosaccharomyces pombe; OBG protein from Bacillus subtilis [PUBMED:12429099]; ferrous iron transport protein B [PUBMED:20123128] and several others.

Reference

  1. Vernet C, Ribouchon MT, Chimini GPontarotti P; , Mamm Genome 1994;5:100-105.: Structure and evolution of a member of a new subfamily of GTP-binding proteins mapping to the human MHC class I region. PUBMED:8180467 EPMC:8180467 .

  2. Bassler J, Kallas M, Hurt E;, J Biol Chem. 2006;281:24737-24744.: The NUG1 GTPase reveals and N-terminal RNA-binding domain that is essential for association with 60 S pre-ribosomal particles. PUBMED:16803892 EPMC:16803892 .

  3. Jain N, Dhimole N, Khan AR, De D, Tomar SK, Sajish M, Dutta D, Parrack P, Prakash B;, Biochem Biophys Res Commun. 2009;379:201-205.: E. coli HflX interacts with 50S ribosomal subunits in presence of nucleotides. PUBMED:19109926 EPMC:19109926 .

  4. Dutta D, Bandyopadhyay K, Datta AB, Sardesai AA, Parrack P;, J Bacteriol. 2009;191:2307-2314.: Properties of HflX, an enigmatic protein from Escherichia coli. PUBMED:19181811 EPMC:19181811 .

  5. Shields MJ, Fischer JJ, Wieden HJ;, Biochemistry. 2009;48:10793-10802.: Toward understanding the function of the universally conserved GTPase HflX from Escherichia coli: a kinetic approach. PUBMED:19824612 EPMC:19824612.