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Nucleoplasmins are also known as chromatin decondensation proteins. They bind to core histones and transfer DNA to them in a reaction that requires ATP. This is thought to play a role in the assembly of regular nucleosomal arrays.
This entry represents the core structural domain for the nucleoplasmin (Np) family of histone chaperone proteins. This core domain is formed by an 8-stranded beta barrel [PUBMED:15576029].
Ito T, Tyler JK, Bulger M, Kobayashi R, Kadonaga JT; , J Biol Chem 1996;271:25041-25048.: ATP-facilitated chromatin assembly with a nucleoplasmin-like protein from Drosophila melanogaster. PUBMED:8798787 EPMC:8798787 .
Frehlick LJ, Eirin-Lopez JM, Ausio J;, Bioessays. 2007;29:49-59.: New insights into the nucleophosmin/nucleoplasmin family of nuclear chaperones. PUBMED:17187372 EPMC:17187372.