Saimiri_boliviensis_boliviensisFamily: zf-C2H2 Number of Genes: 84
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
PRDM4
PATZ1
PRDM10
ZBTB6
-
ZNF317
ZBTB26
ZBTB44
ZBTB34
ZNF319
GZF1
ZNF526
ZBTB37
ZNF768
-
ZNF384
ZFP1
WT1
INSM2
-
ZNF81
ZBTB47
-
BNC1
-
ZNF212
-
ZNF772
PRDM5
ZNF296
-
-
ZNF367
-
MYNN
BNC2
ZBTB49
SALL3
-
ZNF112
ZNF582
ZNF791
-
ZIC3
ZNF226
-
ZSCAN5B
-
RREB1
ZNF564
-
BCL6B
ZEB2
BCL6
ZFP64
ZFHX4
ZNF205
HIC2
ZNF829
ZBTB40
ZFAT
-
ZNF574
-
ZBTB41
ZNF418
ZNF235
SALL2
-
-
ZNF800
ZNF423
-
-
ZNF652
ZNF200
ZFP69B
-
-
ZNF836
ZNF236
SALL4
ZNF2
ZBTB24
ZBTB20
GFI1
ZNF683
SALL1
ZBTB16
ZEB1
ZNF408
ZFHX3
ZBTB14
-
-
SNAI1
SNAI2
ZNF687

Introduction

Pfam

The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [2].

InterPro

No InterPro abstract

Reference

  1. Boehm S, Frishman D, Mewes HW; , Nucleic Acids Res 1997;25:2464-2469.: Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. PUBMED:9171100 EPMC:9171100 .

  2. Marco E, Garcia-Nieto R, Gago F; , J Mol Biol 2003;328:9-32.: Assessment by molecular dynamics simulations of the structural determinants of DNA-binding specificity for transcription factor Sp1. PUBMED:12683994 EPMC:12683994.