EuRBPDB

Drosophila_melanogasterFamily: zf-C2H2_jaz Number of Genes: 11

Ensembl ID	Symbol	Entrez ID
FBgn0004401	Pep	45961
FBgn0027599	CG2790	37992
FBgn0029885	CG3224	31600
FBgn0030010	CG10959	31743
FBgn0030878	CG6769	32770
FBgn0035134	CG1231	38060
FBgn0035520	CG11586	38520
FBgn0037923	CG6813	41396
FBgn0043799	CG31381	192528
FBgn0259789	zld	32994
FBgn0263603	Zn72D	39764

Introduction

Pfam

This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localise in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localisation.

InterPro

This zinc finger is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localise in the nucleus, particularly the nucleolus [PUBMED:10488071]. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localisation.

Reference

Yang M, May WS, Ito T;, J Biol Chem. 1999;274:27399-27406.: JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization. PUBMED:10488071 EPMC:10488071.