Drosophila_melanogasterFamily: GTP_EFTU Number of Genes: 23
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
eEF1alpha2
eEF2
Ras85D
eRF3
waw
mEFTu1
eIF5B
Dgp-1
mEFTu2
eEFSec
CG2017
CG4849
mIF2
Rab21
CG3704
CG13375
Rheb
HBS1
mRRF2
CG33158
mEFG1
eIF2gamma
eEF1alpha1

Introduction

Pfam

This domain contains a P-loop motif, also found in several other families such as PF00071 PF00025 and PF00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.

InterPro

The translational GTPases are the Bacteria elongation factors, EFTu, EFG, and the initiation factor, IF2, and their archaeal homologues, the EF1, EF2, aeIF5b and aeIF2. They all contain two homologous N-terminal domains: a GTPase or G-domain, followed by an OB-domain. These translational proteins' G-domains are both structurally and functionally related to a larger family of GTPase G proteins [PUBMED:11916378].

Reference

  1. Stark H, Rodnina MV, Rinke-Appel J, Brimacombe R, Wintermeyer W, van Heel M; , Nature 1997;389:403-406.: Visualization of elongation factor Tu on the Escherichia coli ribosome. PUBMED:9311785 EPMC:9311785.