Panthera_tigris_altaicaFamily: MMR_HSR1 Number of Genes: 97
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
SEPT8
SAR1B
ARL4A
-
-
-
SEPT2
RRAGB
-
-
HRAS
RASEF
-
SEPT1
RAB39B
-
GNL3L
ARL14
GIMD1
SRPRB
GPN1
RAB33B
NKIRAS2
-
RAB5C
NUGGC
ARL6
GTPBP4
RERG
DRG1
MFN1
-
GNL3
RAB9B
GIMAP8
-
ARF1
RAB23
GUF1
RAB30
ARL4D
LSG1
RAB1B
ARL5B
GNL1
ARL4C
-
SEPT3
-
-
RAB18
ARL10
-
SEPT7
-
NOA1
RAB36
-
GIMAP2
-
-
-
-
-
KRAS
EEF2
EHD3
DNAJC27
RAB1A
-
ERAL1
SEPT4
RAB17
GNL2
ARL2-SNX15
-
SRL
-
SEPT6
SEPT12
SAR1A
DRG2
ARL5A
ARL5C
SEPT11
RAB44
RAB14
RABL3
RAB7A
MTG2
-
RASL11B
EHD2
-
ARF4
NRAS
RAB33A
GTPBP8
-
MFN2
SEPT14
MTIF2
ARL3
ARFRP1
EHD4
EIF5B
RAB34
RAB11A
RAB5A
-
-
RAB2B

Introduction

Pfam

The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.

InterPro

Several proteins have recently been shown to contain the 5 structural motifs characteristic of GTP-binding proteins [PUBMED:1449490]. These include murine DRG protein; GTP1 protein from Schizosaccharomyces pombe; OBG protein from Bacillus subtilis [PUBMED:12429099]; ferrous iron transport protein B [PUBMED:20123128] and several others.

Reference

  1. Vernet C, Ribouchon MT, Chimini GPontarotti P; , Mamm Genome 1994;5:100-105.: Structure and evolution of a member of a new subfamily of GTP-binding proteins mapping to the human MHC class I region. PUBMED:8180467 EPMC:8180467 .

  2. Bassler J, Kallas M, Hurt E;, J Biol Chem. 2006;281:24737-24744.: The NUG1 GTPase reveals and N-terminal RNA-binding domain that is essential for association with 60 S pre-ribosomal particles. PUBMED:16803892 EPMC:16803892 .

  3. Jain N, Dhimole N, Khan AR, De D, Tomar SK, Sajish M, Dutta D, Parrack P, Prakash B;, Biochem Biophys Res Commun. 2009;379:201-205.: E. coli HflX interacts with 50S ribosomal subunits in presence of nucleotides. PUBMED:19109926 EPMC:19109926 .

  4. Dutta D, Bandyopadhyay K, Datta AB, Sardesai AA, Parrack P;, J Bacteriol. 2009;191:2307-2314.: Properties of HflX, an enigmatic protein from Escherichia coli. PUBMED:19181811 EPMC:19181811 .

  5. Shields MJ, Fischer JJ, Wieden HJ;, Biochemistry. 2009;48:10793-10802.: Toward understanding the function of the universally conserved GTPase HflX from Escherichia coli: a kinetic approach. PUBMED:19824612 EPMC:19824612.