Pan_troglodytesFamily: zf-C2H2 Number of Genes: 104
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
ZBTB40
ZNF683
ZNF687
ZBTB37
ZBTB41
ZEB1
WT1
ZNF408
ZBTB16
HINFP
PRDM10
ZNF384
PRDM4
SALL2
INSM2
BNC1
ZNF205
-
MAZ
ZNF267
ZNF423
SALL1
ZFHX3
ZFP1
ZFPM1
SNAI3
BCL6B
ZNF236
SALL3
-
-
ZNF426
ZNF700
ZBTB32
ZNF829
ZNF574
-
ZNF224
ZNF226
ZNF233
ZNF235
ZNF112
ZNF600
ZNF468
ZNF320
-
ZNF860
-
ZNF524
ZNF784
ZNF582
ZNF550
ZSCAN4
ZNF2
ZEB2
GZF1
ZNF337
SALL4
ZFP64
PATZ1
ZBTB47
ZBTB20
-
MYNN
BCL6
ZBTB49
PRDM5
ZNF354A
-
RREB1
ZBTB12
ZBTB24
ZNF800
SNAI2
ZFHX4
ZFAT
BNC2
ZNF484
ZBTB26
PRDM12
-
ZBTB44
ZNF888
ZNF836
ZSCAN5B
ZNF418
-
ZNF155
-
ZBTB14
ZNF319
ZNF317
ZBTB6
ZNF652
-
GFI1
-
-
-
ZSCAN5C
ZIC3
ZBTB34
-
ZNF768
HIC2
-
HIC1
ZNF816
ZNF28
-
-
-
ZNF701
-
SNAI1
ZNF845
ZSCAN5A
ZNF850
-
ZNF628

Introduction

Pfam

The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [2].

InterPro

No InterPro abstract

Reference

  1. Boehm S, Frishman D, Mewes HW; , Nucleic Acids Res 1997;25:2464-2469.: Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. PUBMED:9171100 EPMC:9171100 .

  2. Marco E, Garcia-Nieto R, Gago F; , J Mol Biol 2003;328:9-32.: Assessment by molecular dynamics simulations of the structural determinants of DNA-binding specificity for transcription factor Sp1. PUBMED:12683994 EPMC:12683994.