Pan_paniscusFamily: DEAD Number of Genes: 85
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
HELQ
DDX19A
DDX55
DDX53
DDX42
DHX37
DDX60L
EIF4A2
YTHDC2
DHX36
-
-
HFM1
DHX16
TDRD9
DDX25
POLQ
-
-
DDX1
DDX31
DDX52
SMARCA5
DDX51
-
FANCM
DHX57
DDX56
DDX41
DHX9
RECQL
DHX15
-
-
ASCC3
DHX58
RAD54L
-
-
DDX59
DDX20
BLM
-
-
-
DHX40
DDX18
DDX4
DDX43
DHX30
RECQL5
SMARCA1
DDX6
ERCC6L2
-
-
-
DICER1
DDX49
DDX10
-
-
DDX27
-
DDX21
WRN
DDX28
-
DDX46
DDX23
IFIH1
DDX24
RECQL4
-
-
DHX33
-
-
MTREX
DDX47
EIF4A1
-
-
DDX39A
SKIV2L
-
-
-
-
DDX50
-
-
SNRNP200
DHX29
DDX58
DDX3X
DDX5
DDX54
-
DDX17
DHX38
DDX39B

Introduction

Pfam

Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.

InterPro

Proteins with this domain include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.

Reference

  1. de la Cruz J, Kressler D, Linder P; , Trends Biochem Sci 1999;24:192-198.: Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. PUBMED:10322435 EPMC:10322435 .

  2. Aubourg S, Kreis M, Lecharny A; , Nucleic Acids Res 1999;27:628-636.: The DEAD box RNA helicase family in Arabidopsis thaliana. PUBMED:9862990 EPMC:9862990.