Pan_paniscusFamily: MMR_HSR1 Number of Genes: 117
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
GNL2
ARL4C
RAB9B
RERG
-
-
RAB12
DRG1
GIMAP2
-
RAB23
GIMAP7
RAB6A
RRAGA
SEPT3
ARL5B
ARL14
NKIRAS2
SEPT8
GNL3
ARL4A
IRGC
GPN1
SRPRB
ARFRP1
SEPT14
RAB9A
-
CRACR2A
ARL4D
GTPBP10
GTPBP3
RASL11A
RAB36
MFN2
-
-
-
-
-
HRAS
LSG1
ARF1
ARF3
EIF5B
-
RAB1A
RAB22A
EEFSEC
RAB25
SAR1A
RASL11B
-
GUF1
ARL8A
RAB30
DNAJC27
RAB14
-
-
SEPT1
GTPBP8
SAR1B
GIMAP6
ARL11
ARL5A
NOA1
-
SEPT12
-
-
SEPT2
-
RRAGB
GNL3L
ARL1
SEPT9
ARL3
OLA1
EHD3
RAB5B
RAB2B
ARF4
RABL3
EHD1
RAB34
RAB5C
-
-
-
ARF5
NRAS
RAB33A
KRAS
GIMAP8
GIMAP4
-
EHD2
DNM1L
-
-
-
-
SEPT6
RAB39B
SEPT7
RAB1B
RAB18
ARL2
SEPT11
RAB5A
-
EHD4
GTPBP4
RASEF
EEF2
RAB6B
MTG2
-
ARL8B
-
RAB33B
RAB44
ARL6
MFN1
GNL1

Introduction

Pfam

The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.

InterPro

Several proteins have recently been shown to contain the 5 structural motifs characteristic of GTP-binding proteins [PUBMED:1449490]. These include murine DRG protein; GTP1 protein from Schizosaccharomyces pombe; OBG protein from Bacillus subtilis [PUBMED:12429099]; ferrous iron transport protein B [PUBMED:20123128] and several others.

Reference

  1. Vernet C, Ribouchon MT, Chimini GPontarotti P; , Mamm Genome 1994;5:100-105.: Structure and evolution of a member of a new subfamily of GTP-binding proteins mapping to the human MHC class I region. PUBMED:8180467 EPMC:8180467 .

  2. Bassler J, Kallas M, Hurt E;, J Biol Chem. 2006;281:24737-24744.: The NUG1 GTPase reveals and N-terminal RNA-binding domain that is essential for association with 60 S pre-ribosomal particles. PUBMED:16803892 EPMC:16803892 .

  3. Jain N, Dhimole N, Khan AR, De D, Tomar SK, Sajish M, Dutta D, Parrack P, Prakash B;, Biochem Biophys Res Commun. 2009;379:201-205.: E. coli HflX interacts with 50S ribosomal subunits in presence of nucleotides. PUBMED:19109926 EPMC:19109926 .

  4. Dutta D, Bandyopadhyay K, Datta AB, Sardesai AA, Parrack P;, J Bacteriol. 2009;191:2307-2314.: Properties of HflX, an enigmatic protein from Escherichia coli. PUBMED:19181811 EPMC:19181811 .

  5. Shields MJ, Fischer JJ, Wieden HJ;, Biochemistry. 2009;48:10793-10802.: Toward understanding the function of the universally conserved GTPase HflX from Escherichia coli: a kinetic approach. PUBMED:19824612 EPMC:19824612.