EuRBPDB

Mus_caroliFamily: Exo_endo_phos Number of Genes: 24

Ensembl ID	Symbol	Entrez ID
MGP_CAROLIEiJ_G0014384	Inpp5d	110289786
MGP_CAROLIEiJ_G0015040	Angel2	110297119
MGP_CAROLIEiJ_G0015268	Smpd2	110303460
MGP_CAROLIEiJ_G0016012	Inpp5j	110304984
MGP_CAROLIEiJ_G0016277	Cnot6	110305259
MGP_CAROLIEiJ_G0016745	Inpp5k	110305558
MGP_CAROLIEiJ_G0017978	Angel1	110307064
MGP_CAROLIEiJ_G0018354	Tdp2	110307982
MGP_CAROLIEiJ_G0018938	Dnase1l3	110309519
MGP_CAROLIEiJ_G0019032	Pde12	110309608
MGP_CAROLIEiJ_G0019209	Apex1	110309328
MGP_CAROLIEiJ_G0020396	Dnase1	110311419
MGP_CAROLIEiJ_G0020951	Synj1	110311455
MGP_CAROLIEiJ_G0021026	Synj2	110312552
MGP_CAROLIEiJ_G0021184	Dnase1l2	110284135
MGP_CAROLIEiJ_G0023316	Inpp5e	110309573
MGP_CAROLIEiJ_G0024971	Noct	110291122
MGP_CAROLIEiJ_G0026450	Inpp5b	110292118
MGP_CAROLIEiJ_G0027429	Cnot6l	110294221
MGP_CAROLIEiJ_G0030066	Inppl1	110297343
MGP_CAROLIEiJ_G0030617	Inpp5a	110298346
MGP_CAROLIEiJ_G0033035	Ocrl	110286794
MGP_CAROLIEiJ_G0033177	Dnase1l1	110286589
MGP_CAROLIEiJ_G0033484	Apex2	110286626

Introduction

Pfam

This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g P27695 DNase I proteins EC:3.1.21.1 e.g. P24855 Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 O43426 Sphingomyelinase EC:3.1.4.12 P11889 and Nocturnin O35710.

InterPro

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PUBMED:10838565]. Proteins this domain is found in include: AP endonuclease proteins (EC), DNase I proteins (EC), Synaptojanin an inositol-1,4,5-trisphosphate phosphatase (EC) and Sphingomyelinase (EC).

Reference

Dlakic M; , Trends Biochem Sci 2000;25:272-273.: Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases. PUBMED:10838565 EPMC:10838565 .
Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA; , Nature 1995;374:381-386.: Structure and function of the multifunctional DNA-repair enzyme exonuclease III. PUBMED:7885481 EPMC:7885481 .
Lahm A, Suck D; , J Mol Biol 1991;222:645-667.: DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex. PUBMED:1748997 EPMC:1748997.