Dasypus_novemcinctusFamily: RRM_1 Number of Genes: 254
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
CELF2
SRSF3
-
PTBP1
RBM28
RBM45
HTATSF1
-
-
ALYREF
-
A1CF
SLTM
-
-
TNRC6C
-
-
CSTF2T
-
ENOX1
RBFOX2
NCBP2L
-
HNRNPH3
RBM25
-
MSI1
-
-
-
PPARGC1B
SRSF5
U2SURP
-
-
IGF2BP1
TAF15
-
-
SF3B6
SLIRP
SRSF7
RBPMS
SRSF6
TARDBP
SRSF11
PABPC1
ELAVL1
-
-
-
CNOT4
CELF1
TIAL1
UHMK1
-
-
SREK1
-
-
-
PSPC1
RBM22
RBMS2
-
-
-
-
-
RBM5
-
-
RAVER2
HNRNPM
PTBP3
SRSF9
-
DND1
IGF2BP3
SSB
-
LARP7
-
-
-
RBM41
-
MSI2
ZRSR2
CPSF6
SAFB
HNRNPH2
RNPS1
RBM46
TIA1
RBMS3
BOLL
-
FUS
-
PTBP2
RBM44
-
-
SYNCRIP
-
-
CPSF7
-
-
-
-
HNRNPL
SCAF4
HNRNPA3
-
SART3
-
NOL8
PABPN1
-
-
RBM19
PARP6
-
RBM39
-
-
SCAF8
-
-
-
-
-
HNRNPA0
-
-
-
-
-
PABPC4L
-
-
RBM10
-
-
-
-
-
RBM18
-
-
RBM38
RBM15
-
-
RBM4
RBM23
CELF4
-
-
-
-
-
-
TRNAU1AP
-
-
-
-
ELAVL4
DNAJC17
-
-
-
-
-
-
-
-
-
-
ENOX2
PABPN1L
-
-
-
SETD1B
-
-
-
-
ELAVL2
-
-
-
-
-
-
RBM17
ALKBH8
-
-
-
-
-
-
-
-
RBM15B
-
-
-
-
RBMX2
RBM42
-
-
-
-
SNRNP35
MYEF2
-
-
-
-
-
-
-
RBFOX3
-
TRA2A
-
-
-
-
-
-
-
-
PPIL4
-
-
-
-
-
-
RBMS1
PPRC1
-
-
-
-
-
-
PPARGC1A
-
-
CELF3
RBM12B
-
-
-
-
-
-
SPEN
-
-
-
-
RBM14
PUF60
-
-
-
-
-
RBFOX1
CELF5
-
-
-
-
-
-
-
-
-
-
RBM11
-
-
RBM34
-
-
-
-
HNRNPLL
-
-
-
-
-
-
-
-
-
-
DAZAP1
-
-
-
-
-
-
RBM47
U2AF2
-
-
NCBP2
-
CPEB2
-
-
SRSF4
-
-
-
-
-
-
-
-
-
-
PABPC1L
CPEB3
-
-
RBPMS2
-
-
-
-
-
SFPQ
-
-
-
-
EIF3B
EIF4H
-
-

Introduction

Pfam

The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.

InterPro

Many eukaryotic proteins containing one or more copies of a putative RNA-binding domain of about 90 amino acids are known to bind single-stranded RNAs [PUBMED:3072706, PUBMED:3192525, PUBMED:3313012]. The largest group of single strand RNA-binding proteins is the eukaryotic RNA recognition motif (RRM) family that contains an eight amino acid RNP-1 consensus sequence [PUBMED:2470643, PUBMED:2467746]. RRM proteins have a variety of RNA binding preferences and functions, and include heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing (SR, U2AF, Sxl), protein components of small nuclear ribonucleoproteins (U1 and U2 snRNPs), and proteins that regulate RNA stability and translation (PABP, La, Hu) [PUBMED:3192525, PUBMED:3313012, PUBMED:2467746]. The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialised features for protein recognition [PUBMED:15231733]. The motif also appears in a few single stranded DNA binding proteins.

Reference

  1. Birney E., Kumar S., Krainer A.R. , Nucleic Acid Res 1993;21:5803-5816.: Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. PUBMED:8290338 EPMC:8290338.