Canis_familiarisFamily: DEAD Number of Genes: 69
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
YTHDC2
DHX16
DDX39B
SKIV2L
DDX46
DDX17
RECQL4
DDX58
ASCC3
DDX1
RAD54L
-
-
RECQL5
DDX18
EIF4A3
DHX57
DDX51
WRN
DHX29
MTREX
DDX4
DHX37
DDX55
TDRD12
SMARCA5
DHX36
DDX60
HELQ
CMSS1
TTF2
IFIH1
DDX25
DDX59
DDX27
POLQ
-
DDX5
RECQL
BLM
DDX6
DDX42
DHX30
DHX9
DDX47
-
-
EIF4A2
DDX20
DDX50
DDX21
FANCM
DDX3X
DDX10
DDX49
DHX33
DHX58
DDX41
DDX39A
DHX15
EIF4A1
DDX24
DHX40
DICER1
-
SMARCA1
DDX19A
HFM1
DHX38
DDX28
DDX23
DDX56

Introduction

Pfam

Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.

InterPro

Proteins with this domain include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.

Reference

  1. de la Cruz J, Kressler D, Linder P; , Trends Biochem Sci 1999;24:192-198.: Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. PUBMED:10322435 EPMC:10322435 .

  2. Aubourg S, Kreis M, Lecharny A; , Nucleic Acids Res 1999;27:628-636.: The DEAD box RNA helicase family in Arabidopsis thaliana. PUBMED:9862990 EPMC:9862990.