Sus_scrofaFamily: GTP_EFTU Number of Genes: 30
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
GTPBP1
-
-
GTPBP2
EFL1
HBS1L
-
TUFM
EIF5B
MTIF2
GPN1
GUF1
EEFSEC
-
GSPT2
-
-
-
GFM2
EFTUD2
GSPT1
GFM1
EEF2
KRAS
MRAS
-
-
-
-
-
-
-
-
-
-
-
EEF1A2

Introduction

Pfam

This domain contains a P-loop motif, also found in several other families such as PF00071 PF00025 and PF00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.

InterPro

The translational GTPases are the Bacteria elongation factors, EFTu, EFG, and the initiation factor, IF2, and their archaeal homologues, the EF1, EF2, aeIF5b and aeIF2. They all contain two homologous N-terminal domains: a GTPase or G-domain, followed by an OB-domain. These translational proteins' G-domains are both structurally and functionally related to a larger family of GTPase G proteins [PUBMED:11916378].

Reference

  1. Stark H, Rodnina MV, Rinke-Appel J, Brimacombe R, Wintermeyer W, van Heel M; , Nature 1997;389:403-406.: Visualization of elongation factor Tu on the Escherichia coli ribosome. PUBMED:9311785 EPMC:9311785.