Myotis_lucifugusFamily: zf-C2H2 Number of Genes: 72
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
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-
-
-
ZBTB44
PRDM4
PRDM15
-
SNAI2
ZBTB21
ZFP64
-
-
ZBTB47
-
ZEB2
ZFP1
GTF3A
-
GZF1
-
ZNF454
ZBTB16
-
-
-
-
BNC2
-
ZFAT
-
-
MYNN
-
ZNF646
-
PRDM5
ZNF770
-
-
-
-
-
-
ZNF784
-
SALL2
-
-
ZNF521
-
HIC2
ZNF423
ZBTB49
PATZ1
HIC1
-
SALL3
-
ZEB1
ZNF236
ZBTB32
ZNF800
-
-
ZNF81
ZNF317
BCL6
ZNF652
PRDM10
RREB1
ZNF235
-
ZBTB6
ZBTB20
ZNF112
-
ZNF574
-
GFI1
SALL1
-
-
-
ZFHX3
ZBTB14
-
ZBTB41
ZFHX4
-
ZBTB34
-
ZBTB17
INSM2
-
WT1
-
-
-
-
-
ZBTB24
-
-

Introduction

Pfam

The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [2].

InterPro

No InterPro abstract

Reference

  1. Boehm S, Frishman D, Mewes HW; , Nucleic Acids Res 1997;25:2464-2469.: Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. PUBMED:9171100 EPMC:9171100 .

  2. Marco E, Garcia-Nieto R, Gago F; , J Mol Biol 2003;328:9-32.: Assessment by molecular dynamics simulations of the structural determinants of DNA-binding specificity for transcription factor Sp1. PUBMED:12683994 EPMC:12683994.