EuRBPDB

Mus_musculusFamily: Exo_endo_phos Number of Genes: 29

Ensembl ID	Symbol	Entrez ID
ENSMUSG00000001173	Ocrl	320634
ENSMUSG00000005980	Dnase1	13419
ENSMUSG00000006127	Inpp5k	19062
ENSMUSG00000019088	Dnase1l1	69537
ENSMUSG00000019822	Smpd2	20598
ENSMUSG00000020362	Cnot6	104625
ENSMUSG00000021257	Angel1	68737
ENSMUSG00000022973	Synj1	104015
ENSMUSG00000023087	Noct	12457
ENSMUSG00000023805	Synj2	20975
ENSMUSG00000024136	Dnase1l2	66705
ENSMUSG00000025269	Apex2	77622
ENSMUSG00000025279	Dnase1l3	13421
ENSMUSG00000025477	Inpp5a	212111
ENSMUSG00000026288	Inpp5d	16331
ENSMUSG00000026634	Angel2	52477
ENSMUSG00000026925	Inpp5e	64436
ENSMUSG00000028894	Inpp5b	16330
ENSMUSG00000032737	Inppl1	16332
ENSMUSG00000034570	Inpp5j	170835
ENSMUSG00000034724	Cnot6l	231464
ENSMUSG00000035958	Tdp2	56196
ENSMUSG00000035960	Apex1	11792
ENSMUSG00000043702	Pde12	211948
ENSMUSG00000090353	Gm17555	-
ENSMUSG00000094030	Gm21833	-
ENSMUSG00000094472	Gm21897	-
ENSMUSG00000096463	Gm21750	-
ENSMUSG00000096808	AC132444.6	-

Introduction

Pfam

This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g P27695 DNase I proteins EC:3.1.21.1 e.g. P24855 Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 O43426 Sphingomyelinase EC:3.1.4.12 P11889 and Nocturnin O35710.

InterPro

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PUBMED:10838565]. Proteins this domain is found in include: AP endonuclease proteins (EC), DNase I proteins (EC), Synaptojanin an inositol-1,4,5-trisphosphate phosphatase (EC) and Sphingomyelinase (EC).

Reference

Dlakic M; , Trends Biochem Sci 2000;25:272-273.: Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases. PUBMED:10838565 EPMC:10838565 .
Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA; , Nature 1995;374:381-386.: Structure and function of the multifunctional DNA-repair enzyme exonuclease III. PUBMED:7885481 EPMC:7885481 .
Lahm A, Suck D; , J Mol Biol 1991;222:645-667.: DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex. PUBMED:1748997 EPMC:1748997.