Canis_lupus_dingoFamily: MMR_HSR1 Number of Genes: 120
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
EHD2
SEPT8
-
-
-
RAB33A
-
SAR1B
RASL11B
ARFRP1
RAB6A
LSG1
-
-
-
-
-
GNL3
RAB9A
GUF1
RAB18
GTPBP4
EHD4
RAB36
EEFSEC
RAB7A
RHEB
ARF1
RAB25
SEPT7
RABL3
-
-
GIMAP2
-
GIMAP4
-
GIMAP7
-
GIMAP8
SEPT9
ARF4
RAB15
-
-
RERG
HRAS
-
GTPBP8
RAB44
-
GNL2
RAB11A
RAB39B
MFN2
RAB14
ARL8B
ARL6
GIMD1
ARL3
GTPBP3
-
SEPT11
ARL10
ERAL1
RAB34
ARL5B
-
KRAS
RRAGA
ARL4D
IRGC
-
-
-
-
RAB5C
RRAGB
NKIRAS2
GNL3L
CRACR2A
EHD1
-
-
RAB23
ARL8A
GTPBP10
GNL1
SEPT1
RAB30
-
RAB35
SEPT14
-
-
-
RAB33B
DRG2
ARL14
-
ARF5
-
-
RAB22A
-
RAB11B
MTG2
MFN1
EHD3
RAB12
RASEF
ARL1
ARL4C
-
-
EIF5B
SEPT12
SRL
-
DNAJC27
RASL11A
SAR1A
SEPT4
RAB5B
MTIF2
-
RAB1A
RAB5A
NOA1
ARL5A
SRPRB
-
RAB6B

Introduction

Pfam

The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.

InterPro

Several proteins have recently been shown to contain the 5 structural motifs characteristic of GTP-binding proteins [PUBMED:1449490]. These include murine DRG protein; GTP1 protein from Schizosaccharomyces pombe; OBG protein from Bacillus subtilis [PUBMED:12429099]; ferrous iron transport protein B [PUBMED:20123128] and several others.

Reference

  1. Vernet C, Ribouchon MT, Chimini GPontarotti P; , Mamm Genome 1994;5:100-105.: Structure and evolution of a member of a new subfamily of GTP-binding proteins mapping to the human MHC class I region. PUBMED:8180467 EPMC:8180467 .

  2. Bassler J, Kallas M, Hurt E;, J Biol Chem. 2006;281:24737-24744.: The NUG1 GTPase reveals and N-terminal RNA-binding domain that is essential for association with 60 S pre-ribosomal particles. PUBMED:16803892 EPMC:16803892 .

  3. Jain N, Dhimole N, Khan AR, De D, Tomar SK, Sajish M, Dutta D, Parrack P, Prakash B;, Biochem Biophys Res Commun. 2009;379:201-205.: E. coli HflX interacts with 50S ribosomal subunits in presence of nucleotides. PUBMED:19109926 EPMC:19109926 .

  4. Dutta D, Bandyopadhyay K, Datta AB, Sardesai AA, Parrack P;, J Bacteriol. 2009;191:2307-2314.: Properties of HflX, an enigmatic protein from Escherichia coli. PUBMED:19181811 EPMC:19181811 .

  5. Shields MJ, Fischer JJ, Wieden HJ;, Biochemistry. 2009;48:10793-10802.: Toward understanding the function of the universally conserved GTPase HflX from Escherichia coli: a kinetic approach. PUBMED:19824612 EPMC:19824612.