Macaca_fascicularisFamily: RRM_1 Number of Genes: 229
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
RBMS1
-
-
RBM18
PPARGC1A
DAZAP1
SFPQ
-
-
-
-
-
NCBP2
ALYREF
CPSF7
IGF2BP1
MSI1
SRSF7
RNPC3
RBMS2
PPIE
RBFOX3
HNRNPDL
SRSF5
DAZL
RBM44
-
-
HNRNPC
HNRNPA2B1
-
-
-
SRSF3
TARDBP
RBM42
TIAL1
-
-
PABPN1L
IGF2BP3
CPEB4
ALKBH8
ENOX2
DND1
-
-
SETD1A
EIF3G
CELF1
ELAVL3
RBM3
MSI2
RBM4
-
-
SAFB
-
RBM22
-
-
CPEB2
PTBP2
SNRNP35
PABPC3
-
-
-
HNRNPF
-
-
-
PABPC5
ENOX1
CPEB3
-
-
HNRNPH1
-
-
SRSF8
-
-
RBM15B
RBM15
-
-
-
-
HNRNPA0
-
-
SETD1B
BOLL
RBM28
U2SURP
-
-
-
-
-
-
-
-
NIFK
SNRPB2
-
-
RAVER2
HNRNPA1
RBM5
HNRNPD
-
-
FUS
EIF4H
RBFOX2
BCL2L2-PABPN1
DNAJC17
-
RBM10
RBMX
RBM12
PPIL4
PSPC1
SCAF8
-
-
RDM1
CELF2
RALY
RBMS3
SLTM
-
-
-
-
RBM4B
-
-
CIRBP
-
-
-
-
ZNF638
RBM24
NOL8
-
-
-
-
HNRNPAB
RBM17
A1CF
-
-
RBFOX1
LARP7
SRSF12
REXO5
HNRNPLL
RBPMS
SRSF6
G3BP1
TDRD10
-
-
-
-
-
GRSF1
RBM23
HNRNPM
SCAF4
-
RBMXL2
-
RBM47
RAVER1
SF3B6
-
U2AF2
RBM34
PPRC1
EWSR1
SSB
-
-
SRSF9
RBM11
-
-
IGF2BP2
HNRNPH3
ZRSR2
ELAVL2
SAFB2
HNRNPR
ZCRB1
-
SREK1
SNRNP70
ELAVL4
SART3
-
RBM25
-
-
-
-
CELF3
PABPC1L
NCL
ELAVL1
RBMX2
PTBP3
RBM41
-
-
PABPC4
NONO
SNRPA
-
-
UHMK1
SRSF4
TAF15
SPEN
-
-
RNPS1
PPARGC1B
SF3B4
-
-
-
-
RBM45
RBM39
-
TRA2B
-
-
SLIRP
CELF4
TRA2A
PUF60
SRSF11
RBM46
TRNAU1AP
-
-
RBM38
CSTF2
TNRC6C
-
-
POLDIP3
MTHFSD
HTATSF1
G3BP2
PABPC1
-
-
-
-
CPSF6
RBPMS2
RBM8A
RBM12B
-
SRSF2
TIA1
SRSF10
RBM19
EIF3B
CNOT4
MYEF2

Introduction

Pfam

The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.

InterPro

Many eukaryotic proteins containing one or more copies of a putative RNA-binding domain of about 90 amino acids are known to bind single-stranded RNAs [PUBMED:3072706, PUBMED:3192525, PUBMED:3313012]. The largest group of single strand RNA-binding proteins is the eukaryotic RNA recognition motif (RRM) family that contains an eight amino acid RNP-1 consensus sequence [PUBMED:2470643, PUBMED:2467746]. RRM proteins have a variety of RNA binding preferences and functions, and include heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing (SR, U2AF, Sxl), protein components of small nuclear ribonucleoproteins (U1 and U2 snRNPs), and proteins that regulate RNA stability and translation (PABP, La, Hu) [PUBMED:3192525, PUBMED:3313012, PUBMED:2467746]. The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialised features for protein recognition [PUBMED:15231733]. The motif also appears in a few single stranded DNA binding proteins.

Reference

  1. Birney E., Kumar S., Krainer A.R. , Nucleic Acid Res 1993;21:5803-5816.: Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. PUBMED:8290338 EPMC:8290338.