EuRBPDB

Drosophila_melanogasterFamily: LSM Number of Genes: 18

Ensembl ID	Symbol	Entrez ID
FBgn0000426	SmF	36314
FBgn0023167	SmD3	36306
FBgn0032240	CG17768	3772012
FBgn0033450	Lsm11	36013
FBgn0033554	Lsm10	36141
FBgn0034564	CG9344	37372
FBgn0035271	CG2021	38229
FBgn0035675	CG6610	38693
FBgn0036277	CG10418	39408
FBgn0051184	LSm3	42842
FBgn0051950	CG31950	319043
FBgn0261067	LSm1	37413
FBgn0261068	LSm7	35003
FBgn0261789	SmD2	40781
FBgn0261790	SmE	34080
FBgn0261791	SNRPG	32636
FBgn0261933	SmD1	44668
FBgn0262601	SmB	34426

Introduction

Pfam

The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.

InterPro

This domain is found in Lsm (like-Sm) proteins, which have a core structure consisting of an open beta-barrel with an SH3-like topology.

Reference

Hermann H, Fabrizio P, Raker VA, Foulaki K, Hornig H, Brahms H, Luhrmann R , EMBO J 1995;14:2076-2088.: snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions. PUBMED:7744013 EPMC:7744013 .
Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Luhrmann R, Li J, Nagai K; , Cell 1999;96:375-387.: Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs. PUBMED:10025403 EPMC:10025403 .
Mayes AE, Verdone L, Legrain P, Beggs JD; , EMBO J 1999;18:4321-4331.: Characterization of Sm-like proteins in yeast and their association with U6 snRNA. PUBMED:10428970 EPMC:10428970 .
Hajnsdorf E, Regnier P; , Proc Natl Acad Sci U S A 2000;97:1501-1505.: Host factor Hfq of Escherichia coli stimulates elongation of poly(A) tails by poly(A) polymerase I. PUBMED:10677490 EPMC:10677490 .
Vytvytska O, Moll I, Kaberdin VR, von Gabain A, Blasi U; , Genes Dev 2000;14:1109-1118.: Hfq (HF1) stimulates ompA mRNA decay by interfering with ribosome binding. PUBMED:10809669 EPMC:10809669 .
Kufel J, Allmang C, Petfalski E, Beggs J, Tollervey D; , J Biol Chem 2003;278:2147-2156.: Lsm Proteins are required for normal processing and stability of ribosomal RNAs. PUBMED:12438310 EPMC:12438310.