Cavia_porcellusFamily: zf-C2H2 Number of Genes: 74
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
ZNF423
PRDM10
ZFP1
-
ZNF574
HIC2
ZNF367
ZIC3
-
ZBTB24
ZBTB44
ZBTB34
ZNF317
BCL6B
BCL6
ZBTB16
ZEB2
ZBTB41
ZNF768
-
PRDM12
-
BNC2
SALL1
ZNF202
ZNF800
ZEB1
ZBTB49
ZNF236
SALL3
-
BNC1
ZFHX3
GTF3A
-
ZNF687
GZF1
MYNN
GFI1
ZNF384
ZFHX4
ZBTB40
PRDM5
INSM2
-
HIC1
-
ZBTB45
ZBTB20
PRDM4
ZFPM1
ZFP64
ZBTB47
-
ZBTB14
-
SNAI1
PRDM14
-
-
ZNF319
ZNF81
-
ZBTB26
WT1
-
-
-
-
-
ZNF526
ZNF646
-
-
ZNF112
-
ZNF2
-
-
-
-
ZNF212
-
-
ZNF784
ZBTB6
ZNF235
-
ZNF652
SALL2
ZNF865
-
ZNF226

Introduction

Pfam

The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [2].

InterPro

No InterPro abstract

Reference

  1. Boehm S, Frishman D, Mewes HW; , Nucleic Acids Res 1997;25:2464-2469.: Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. PUBMED:9171100 EPMC:9171100 .

  2. Marco E, Garcia-Nieto R, Gago F; , J Mol Biol 2003;328:9-32.: Assessment by molecular dynamics simulations of the structural determinants of DNA-binding specificity for transcription factor Sp1. PUBMED:12683994 EPMC:12683994.