Latimeria_chalumnaeFamily: zf-C2H2 Number of Genes: 63
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
ZFPM2
ZNF319
-
ZNF131
-
-
ZBTB6
ZNF628
-
BNC2
SALL1
SCRT1
ZBTB41
-
ZBTB46
-
-
-
-
snai2
ZBTB20
ZBTB12
ZNF521
-
HIC1
-
-
PRDM4
ZNF652
-
ZBTB49
ZNF277
ZBTB45
-
-
PRDM5
RREB1
-
-
-
ZEB2
ZNF581
-
INSM1
ZNF384
MAZ
-
ZFAT
-
ZNF236
-
ZBTB14
OVOL2
ZBTB24
-
HIC2
-
GFI1B
-
-
ZNF423
ZNF800
ZEB1
GFI1
-
SALL4
-
-
-
ZBTB44
ZIC3
-
ZBTB34
PRDM15
-
WT1
ZBTB37
-
BNC1
PRDM12
-
-
INSM2
-
SNAI1
ZFPM1
-
-

Introduction

Pfam

The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [2].

InterPro

No InterPro abstract

Reference

  1. Boehm S, Frishman D, Mewes HW; , Nucleic Acids Res 1997;25:2464-2469.: Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. PUBMED:9171100 EPMC:9171100 .

  2. Marco E, Garcia-Nieto R, Gago F; , J Mol Biol 2003;328:9-32.: Assessment by molecular dynamics simulations of the structural determinants of DNA-binding specificity for transcription factor Sp1. PUBMED:12683994 EPMC:12683994.