EuRBPDB

Danio_rerioFamily: Exo_endo_phos Number of Genes: 40

Ensembl ID	Symbol	Entrez ID
ENSDARG00000001442	inppl1b	368433
ENSDARG00000005464	dnase1l1	792196
ENSDARG00000008255	cnot6a	324048
ENSDARG00000008472	apex2	393115
ENSDARG00000011376	dnase1l4.2	393843
ENSDARG00000012539	dnase1	436947
ENSDARG00000015123	dnase1l4.1	445317
ENSDARG00000016743	angel2	562704
ENSDARG00000023861	dnase1l1l	436676
ENSDARG00000025011	synj1	337236
ENSDARG00000030964	pde12	692319
ENSDARG00000035954	tdp2b	553516
ENSDARG00000040523	smpd2a	567548
ENSDARG00000045843	apex1	406730
ENSDARG00000052701	smpd2b	797914
ENSDARG00000053878	inpp5l	641571
ENSDARG00000054597	cnot6l	553665
ENSDARG00000059811	smpd5	567592
ENSDARG00000069941	tdp2a	101887157
ENSDARG00000074283	inpp5d	559103
ENSDARG00000077567	angel1	569547
ENSDARG00000077726	nocta	572044
ENSDARG00000078106	ocrl	777716
ENSDARG00000078525	noctb	568973
ENSDARG00000078542	inpp5ja	-
ENSDARG00000078618	inpp5kb	566188
ENSDARG00000086613	si:dkey-266f7.10	110438134
ENSDARG00000088493	si:ch211-149k12.3	-
ENSDARG00000093359	inpp5jb	100317089
ENSDARG00000094886	si:dkey-266f7.5	100006143
ENSDARG00000098779	BX547930.4	-
ENSDARG00000099201	BX908731.1	-
ENSDARG00000099563	inpp5ka	100037338
ENSDARG00000101072	cnot6b	560386
ENSDARG00000101795	CABZ01033394.1	-
ENSDARG00000103037	CR848788.1	-
ENSDARG00000103436	BX548028.1	-
ENSDARG00000103683	inpp5b	563543
ENSDARG00000103926	inpp5e	606579
ENSDARG00000104222	inppl1a	325179

Introduction

Pfam

This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g P27695 DNase I proteins EC:3.1.21.1 e.g. P24855 Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 O43426 Sphingomyelinase EC:3.1.4.12 P11889 and Nocturnin O35710.

InterPro

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PUBMED:10838565]. Proteins this domain is found in include: AP endonuclease proteins (EC), DNase I proteins (EC), Synaptojanin an inositol-1,4,5-trisphosphate phosphatase (EC) and Sphingomyelinase (EC).

Reference

Dlakic M; , Trends Biochem Sci 2000;25:272-273.: Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases. PUBMED:10838565 EPMC:10838565 .
Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA; , Nature 1995;374:381-386.: Structure and function of the multifunctional DNA-repair enzyme exonuclease III. PUBMED:7885481 EPMC:7885481 .
Lahm A, Suck D; , J Mol Biol 1991;222:645-667.: DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex. PUBMED:1748997 EPMC:1748997.