Macaca_mulattaFamily: RRM_1 Number of Genes: 240
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
GRSF1
RBPMS
PTBP3
-
EIF4B
-
-
TIA1
TRA2B
PPRC1
SF3B6
CPEB2
TIAL1
SCAF4
PPARGC1A
-
RBM45
MSI2
-
-
ENOX1
-
RBM25
HNRNPLL
U2SURP
CPSF6
DAZAP1
SETD1A
-
-
-
-
RBFOX1
HNRNPA2B1
-
-
-
-
HNRNPAB
RBMS3
RBM27
DND1
NOL8
SRSF1
PPARGC1B
U2AF2
HNRNPL
RBM5
SNRNP70
ALKBH8
-
RBM12B
EIF4H
TRA2A
HTATSF1
ELAVL1
TRNAU1AP
-
SRSF6
RDM1
CELF4
A1CF
SRSF4
ZNF638
RBM28
SF3B4
TARDBP
PABPC4
RBM26
SRSF8
NCBP2
-
-
-
-
SPEN
RBMX2
-
-
SNRNP35
RBMXL2
RBM44
-
HNRNPH3
ELAVL2
-
RBM19
-
-
CELF6
HNRNPH1
HNRNPR
SRSF7
DAZL
RBM24
RBM18
IGF2BP1
-
PABPC5
CELF1
-
-
TNRC6C
-
-
RBM47
RBM7
PABPN1L
SYNCRIP
SETD1B
ALYREF
HNRNPA1
CSTF2
DNAJC17
ENOX2
RBPMS2
PUF60
SRSF10
-
SRSF11
RBFOX2
SRSF3
SREK1
G3BP1
BCL2L2-PABPN1
HNRNPC
RAVER1
SRSF12
RBM15
CPEB3
RBM17
SCAF8
CPSF7
-
-
EIF3B
HNRNPDL
RBM8A
PTBP2
-
-
CNOT4
-
SRSF9
-
-
-
REXO5
RBMS1
CELF3
SART3
EIF3G
ZCRB1
-
-
RBM10
PABPC1
LARP7
SAFB2
SAFB
RNPC3
RALY
NCL
-
-
RBM23
RAVER2
HNRNPM
-
-
MYEF2
PPIE
RBM42
SFPQ
-
-
RBMS2
MTHFSD
-
UHMK1
TDRD10
HNRNPH2
FUS
CPEB4
RBM11
PSPC1
RBM14
NONO
ELAVL3
RBM22
PABPC3
-
-
-
NIFK
CPNE1
HNRNPF
RBM46
EWSR1
ELAVL4
SNRPA
CIRBP
SLTM
SUSD6
SRSF2
-
-
-
RBFOX3
SSB
PPIL4
RBM41
IGF2BP2
BOLL
SLIRP
-
-
-
-
-
-
-
-
RBM39
RBM38
MSI1
-
-
-
CELF2
-
-
-
-
-
RBMXL1
-
-
-
-
-
-
-
-
-
-
-
RBM34
-
-
-
-
-
-
-
SNRPB2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
G3BP2
-
-
-
-
-
-
-
-
-
-
-
-
POLDIP3
-
-
-
-
-
-
TAF15
-
-

Introduction

Pfam

The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.

InterPro

Many eukaryotic proteins containing one or more copies of a putative RNA-binding domain of about 90 amino acids are known to bind single-stranded RNAs [PUBMED:3072706, PUBMED:3192525, PUBMED:3313012]. The largest group of single strand RNA-binding proteins is the eukaryotic RNA recognition motif (RRM) family that contains an eight amino acid RNP-1 consensus sequence [PUBMED:2470643, PUBMED:2467746]. RRM proteins have a variety of RNA binding preferences and functions, and include heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing (SR, U2AF, Sxl), protein components of small nuclear ribonucleoproteins (U1 and U2 snRNPs), and proteins that regulate RNA stability and translation (PABP, La, Hu) [PUBMED:3192525, PUBMED:3313012, PUBMED:2467746]. The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialised features for protein recognition [PUBMED:15231733]. The motif also appears in a few single stranded DNA binding proteins.

Reference

  1. Birney E., Kumar S., Krainer A.R. , Nucleic Acid Res 1993;21:5803-5816.: Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. PUBMED:8290338 EPMC:8290338.