Oryzias_melastigmaFamily: zf-C2H2 Number of Genes: 235
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
zbtb16b
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si:ch211-216l23.1
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hinfp
znf384l
rreb1a
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zfhx3
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zbtb16a
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scrt2
bcl6aa
zbtb49
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scrt1b
wt1b
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prdm12b
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hic1
prdm5
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snai2
patz1
zbtb41
zbtb37
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zbtb44
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zgc:66448
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INSM2
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zbtb18
sall3a
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ZBTB21
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zbtb17
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e4f1
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wt1a
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sall2
znf319b
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si:ch211-212k18.5
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znf341
zfhx4
zbtb34
insm1b
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GFI1B
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znf646
znf574
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bcl6ab
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sall1a
zfpm1
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GFI1
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sall4
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zbtb48
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znf512
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hic2
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insm1a
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zeb2b
si:dkey-89b17.4
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znf131
si:ch211-236k19.4
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znf652
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zbtb20
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snai1a
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Introduction

Pfam

The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [2].

InterPro

No InterPro abstract

Reference

  1. Boehm S, Frishman D, Mewes HW; , Nucleic Acids Res 1997;25:2464-2469.: Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. PUBMED:9171100 EPMC:9171100 .

  2. Marco E, Garcia-Nieto R, Gago F; , J Mol Biol 2003;328:9-32.: Assessment by molecular dynamics simulations of the structural determinants of DNA-binding specificity for transcription factor Sp1. PUBMED:12683994 EPMC:12683994.