Sus_scrofaFamily: MMR_HSR1 Number of Genes: 118
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
SEPT3
CRACR2A
ARL1
GNL1
RAB44
RAB15
IRGC
MFN2
IFI44
HBS1L
ARF6
RRAGA
RAB14
RAB2A
-
RAB22A
SEPT1
SRL
EIF5B
RAB1A
MTIF2
GPN1
DNAJC27
GUF1
RASL11B
SEPT11
DRG1
RAB36
-
SAR1A
GNL3
-
RAB7A
EEFSEC
SRPRB
ARL14
LSG1
RAB9A
GNL3L
RAB33A
-
RAB1B
EHD1
RAB11B
-
SEPT8
SAR1B
RAB6A
RAB30
-
OLA1
SEPT2
RHEB
GIMAP2
GIMAP8
ARF5
SEPT7
SEPT9
-
ARL4D
NKIRAS2
SEPT4
RAB34
ERAL1
EHD4
RAB33B
EHD2
RAB39B
NKIRAS1
-
EEF2
NOA1
KRAS
-
ARL6
-
GTPBP4
RAB18
-
RAB23
RAB2B
ARL10
-
-
ARL5B
HRAS
ARL5A
GNL2
ARL3
ARF4
-
-
RAB11A
RAB5C
NRAS
RAB9B
ARL4A
-
RAB35
ARL4C
ARL2-SNX15
RABL3
ARFRP1
EHD3
DRG2
RAB6B
ARL11
-
GTPBP8
ARL8A
RRAGB
MTG2
-
RAB5A
RAB12
GTPBP3
RAB25
MFN1
-
GIMD1
-

Introduction

Pfam

The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.

InterPro

Several proteins have recently been shown to contain the 5 structural motifs characteristic of GTP-binding proteins [PUBMED:1449490]. These include murine DRG protein; GTP1 protein from Schizosaccharomyces pombe; OBG protein from Bacillus subtilis [PUBMED:12429099]; ferrous iron transport protein B [PUBMED:20123128] and several others.

Reference

  1. Vernet C, Ribouchon MT, Chimini GPontarotti P; , Mamm Genome 1994;5:100-105.: Structure and evolution of a member of a new subfamily of GTP-binding proteins mapping to the human MHC class I region. PUBMED:8180467 EPMC:8180467 .

  2. Bassler J, Kallas M, Hurt E;, J Biol Chem. 2006;281:24737-24744.: The NUG1 GTPase reveals and N-terminal RNA-binding domain that is essential for association with 60 S pre-ribosomal particles. PUBMED:16803892 EPMC:16803892 .

  3. Jain N, Dhimole N, Khan AR, De D, Tomar SK, Sajish M, Dutta D, Parrack P, Prakash B;, Biochem Biophys Res Commun. 2009;379:201-205.: E. coli HflX interacts with 50S ribosomal subunits in presence of nucleotides. PUBMED:19109926 EPMC:19109926 .

  4. Dutta D, Bandyopadhyay K, Datta AB, Sardesai AA, Parrack P;, J Bacteriol. 2009;191:2307-2314.: Properties of HflX, an enigmatic protein from Escherichia coli. PUBMED:19181811 EPMC:19181811 .

  5. Shields MJ, Fischer JJ, Wieden HJ;, Biochemistry. 2009;48:10793-10802.: Toward understanding the function of the universally conserved GTPase HflX from Escherichia coli: a kinetic approach. PUBMED:19824612 EPMC:19824612.